An Unsupported Preference for Intravenous Antibiotics

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An Unsupported Preference for Intravenous Antibiotics

1 Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford University Hospitals, Oxford, United Kingdom, 2 Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya, 3 Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, 4 Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi,...

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Hyperostotic chronic sinusitis as an indication for outpatient intravenous antibiotics.

OBJECTIVES There is a subset of patients with chronic rhinosinusitis (CRS) that demonstrate osteitis of the sinuses. Osteitic bone is evident on computed tomography (CT) as hyperostosis. We propose treatment of this entity with a six week course of outpatient intravenous antibiotics in an approach similar to that used in the orthopedic literature for long bone osteomyelitis. This group of patie...

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Home intravenous antibiotics for cystic fibrosis.

BACKGROUND Recurrent endobronchial infection in cystic fibrosis (CF) requires treatment with intravenous antibiotics for several weeks usually in hospital, affecting health costs and quality of life for patients and their families. OBJECTIVES To determine whether home intravenous antibiotic therapy in CF is as effective as inpatient intravenous antibiotic therapy and if it is preferred by ind...

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Intravenous antibiotics and Pseudomonas aeruginosa

We believe that prompt initiation of eradication protocols for new Pseudomonas aeruginosa infection and early, high dose intravenous antibiotic treatment of respiratory exacerbations have been the most important factors responsible for the improved outlook for people with CF (Conway et al, 1985; Smith et al, 1988; Regelmann et al, 1990; Bradley et al, 1999). All patients require regular respira...

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Results of a pilot trial comparing prolonged intravenous antibiotics with sequential intravenous/oral antibiotics for children with perforated appendicitis.

HYPOTHESIS For children with perforated appendicitis, the use of a prolonged course of intravenous (i.v.) antibiotics is equivalent to a short course of i.v. antibiotics followed by sequential conversion to oral (PO) antibiotics. DESIGN Prospective, randomized, clinical trial. SETTING Multicenter study in tertiary children's hospitals. PATIENTS Children (aged 5-18 years) with perforated a...

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ژورنال

عنوان ژورنال: PLOS Medicine

سال: 2015

ISSN: 1549-1676

DOI: 10.1371/journal.pmed.1001825